Ultrasound targeted CNS gene delivery for Parkinson's disease treatment

Ching Hsiang Fan, Chung Yin Lin, Hao Li Liu, Chih Kuang Yeh

研究成果: Review article同行評審

39 引文 斯高帕斯(Scopus)

摘要

Parkinson's disease (PD) is a potent neurodegenerative disease in which a progressive loss of dopaminergic neurons eventually produces a loss of movement control and other symptoms. To date, in addition to pharmacological, non-pharmacological, and neurosurgical therapies, gene delivery has emerged as a potential therapeutic modality for PD. Effective targeted gene delivery is complicated in that gene vectors cannot penetrate the blood-brain barrier (BBB), thus clinical tests must rely on invasive intracerebral gene vector injection. Burst low-pressure focused ultrasound exposure with microbubbles has been demonstrated to noninvasively target and temporally open the BBB, opening new opportunities to transport large molecule substances into the brain for central nervous system (CNS) disease treatment, and raising the potential for noninvasive gene delivery for PD treatment. This paper reviews the underlying mechanism and current progress for focused ultrasound induced CNS gene delivery, and summarizes potential directions for further ultrasound-medicated PD gene therapy.

原文English
頁(從 - 到)246-262
頁數17
期刊Journal of Controlled Release
261
DOIs
出版狀態Published - 2017 九月 10

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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