TY - JOUR
T1 - Uncertainty in cancer risk at low doses of inorganic arsenic
AU - Brown, Kenneth G.
AU - Guo, How Ran
AU - Greene, Howard L.
PY - 1997
Y1 - 1997
N2 - It is unknown whether inorganic arsenic in drinking water concentrations at the current maximum contaminant level of 50 μg/l poses a cancer risk in the United States. Data from two large epidemiological studies of cancer and arsenic in drinking water in Taiwan indicate a dose-response relationship, but the magnitude of risk at low concentrations is highly uncertain. Four sources of uncertainty are described: model choice, data aggregation, intra-village variability of arsenic in well water, arsenic intake from food. New data from an appropriately designed epidemiological study are needed to improve dose-response assessment.
AB - It is unknown whether inorganic arsenic in drinking water concentrations at the current maximum contaminant level of 50 μg/l poses a cancer risk in the United States. Data from two large epidemiological studies of cancer and arsenic in drinking water in Taiwan indicate a dose-response relationship, but the magnitude of risk at low concentrations is highly uncertain. Four sources of uncertainty are described: model choice, data aggregation, intra-village variability of arsenic in well water, arsenic intake from food. New data from an appropriately designed epidemiological study are needed to improve dose-response assessment.
UR - http://www.scopus.com/inward/record.url?scp=21744438313&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21744438313&partnerID=8YFLogxK
U2 - 10.1080/10807039709383693
DO - 10.1080/10807039709383693
M3 - Article
AN - SCOPUS:21744438313
SN - 1080-7039
VL - 3
SP - 351
EP - 362
JO - Human and Ecological Risk Assessment (HERA)
JF - Human and Ecological Risk Assessment (HERA)
IS - 3
ER -
