Unravelling the neuropathogenesis of Japanese encephalitis

Khin Saw Aye Myint, Robert V. Gibbons, Guey Chuen Perng, Tom Solomon

研究成果: Review article同行評審

17 引文 斯高帕斯(Scopus)

摘要

Japanese encephalitis is a devastating disease that causes a frequently fatal encephalitis and is a major health problem throughout much of Asia. Mortality rates can be as high as 30%, with one-third of survivors suffering severe neurological sequelae. Viral cytopathology is important, but the contribution of blood-brain barrier breakdown, the inflammatory response and bystander cell death are unknown. Studies that address the mechanisms producing neuronal dysfunction and damage are required, including the examination of autopsy tissues. A better understanding of these mechanisms may lead to therapeutic strategies to reduce brain injury and neurological sequelae.

原文English
頁(從 - 到)955-956
頁數2
期刊Transactions of the Royal Society of Tropical Medicine and Hygiene
101
發行號10
DOIs
出版狀態Published - 2007 十月

All Science Journal Classification (ASJC) codes

  • 寄生物學
  • 公共衛生、環境和職業健康
  • 傳染性疾病

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