Urinary 1-hydroxypyrene-glucuronide as a biomarker of exposure to various vehicle exhausts among highway toll-station workers in Taipei, Taiwan

Ching Huang Lai, Saou Hsing Liou, Tung Sheng Shih, Perng Jy Tsai, Hsiao Lung Chen, Timothy J. Buckley, Paul T. Strickland, Jouni J.K. Jaakkola

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

In this cross-sectional study, the authors evaluated urinary 1-hydroxypyrene-glucuronide (1-OHP-gluc) as a potential biomarker of exposure to various traffic exhausts. Subjects were 47 female highway toll-station workers and 27 female office workers in training for toll-station employment in Taipei, Taiwan. The mean concentration of urinary 1-OHP-gluc was 0.117 pmol/mol creatinine in the exposed group and 0.073 μmol/mol creatinine in the reference group (difference in mean concentrations: 0.044 μmol/mol creatinine [95% confidence interval [CI]: 0.015, 0.072). In the lanes where tolls were collected from passenger cars, there was a significant relationship between cumulative traffic and 1-OHP-gluc concentration (i.e., average increase of 0.015 μmol/mol creatinine [95% CI: 0.003, 0.027] per 1,000 vehicles). The average increase for truck/bus lanes was similar to that identified for the car lanes (i.e., average increase of 0.011 μmol/mol creatinine [95% CI: -0.024, 0.045] per 1,000 vehicles). The authors determined that exposure to various traffic exhausts increased the urinary concentration of 1-OHP-gluc in a dose-response pattern, which suggests that this chemical may be a useful biomarker for exposure to vehicle exhausts.

原文English
頁(從 - 到)61-69
頁數9
期刊Archives of Environmental Health
59
發行號2
DOIs
出版狀態Published - 2004 二月

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Environmental Science(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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