Use of hydrochlorothiazide and risk of skin cancer: a nationwide Taiwanese case–control study

Anton Pottegård, Sidsel Arnspang Pedersen, Sigrun Alba Johannesdottir Schmidt, Chaw Ning Lee, Chao Kai Hsu, Tzu Chi Liao, Shih Chieh Shao, Edward Chia Cheng Lai

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

Background: The antihypertensive agent hydrochlorothiazide has been associated with increased risks of non-melanoma skin cancer (NMSC) and possibly some melanoma subtypes. Previous studies were, however, conducted in predominantly Caucasian populations. We therefore examined the association between hydrochlorothiazide and skin cancer risk in an Asian population. Methods: By using Taiwan’s National Health Insurance Research Database (NHIRD), we conducted three separate case–control studies of lip cancer, non-lip non-melanoma skin cancer and melanoma. Cases (n = 29,082) with a first-ever skin cancer diagnoses (2008–2015) were matched 1:10 to population controls. We estimated odds ratios (ORs) associating hydrochlorothiazide use with skin cancer risk by using conditional logistic regression. Results: Hydrochlorothiazide use showed no overall association with any of the three outcomes: ORs for high cumulative use of HCTZ (≥50,000 mg) were 0.86 (95% CI 0.09–7.81) for lip cancer, 1.16 (95% CI 0.98–1.37) for non-lip NMSC and 1.07 (95% CI 0.65–1.76) for melanoma. There was some evidence of a dose–response pattern for non-lip NMSC, with an OR of 1.66 (95% CI 0.82–3.33) for 100,000–149,999 mg of HCTZ. The null findings were robust across subgroup and sensitivity analyses. Conclusion: Use of HCTZ appears safe in terms of skin cancer risk in an Asian population.

原文English
頁(從 - 到)973-978
頁數6
期刊British Journal of Cancer
121
發行號11
DOIs
出版狀態Published - 2019 十一月 26

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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