Using developed transdermal delivery chip to transfer drug for skin permeation

Zi Yu Liu, Lin Tsung Chiou, Chia Hsien Yeh, Yu-Cheng Lin

研究成果: Conference contribution

摘要

This study developed a novel transdermal delivery chip system for delivering silver sulfadiazine into rat skin. The chip system was used Micro-Electro-Mechanical-Systems (MEMS) technology to fabricate and electroporation as experimental mechanism. The electrode would generate cell-penetrating electric field in the skin between electrodes when the voltage was applied. Microscope raman spectrometer was used to analyze spectral strength of drug which indicates the drug delivery effect. An excellent transdermal delivery could be obtained and the silver sulfadiazine could be delivered to 200 μ m deep in the rat skin when the voltage at 30 V and the frequency at 0.01 Hz were used. Therefore, this chip system could enhance effectively the transdermal delivery and delivery depth.

原文English
主出版物標題2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009
頁面294-297
頁數4
DOIs
出版狀態Published - 2009 十二月 1
事件2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009 - Tainan, Taiwan
持續時間: 2009 十月 182009 十月 21

出版系列

名字2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009

Other

Other2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009
國家Taiwan
城市Tainan
期間09-10-1809-10-21

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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