TY - JOUR
T1 - Using MicroRNA Arrays as a Tool to Evaluate COVID-19 Vaccine Efficacy
AU - Lin, Yen Pin
AU - Hsieh, Yi Shan
AU - Cheng, Mei Hsiu
AU - Shen, Ching Fen
AU - Shen, Ching Ju
AU - Cheng, Chao Min
N1 - Funding Information:
This research was funded by the Taiwan’s National Science and Technology Council (NSTC 111-2314-B-006-085 & NSTC 111-2628-E-007-005-MY2) and Taiwan’s Kaohsiung Medical University Hospital (KMUH110-0M42).
Publisher Copyright:
© 2022 by the authors.
PY - 2022/10
Y1 - 2022/10
N2 - In order to solve COVID-19 pandemic, the entire world has invested considerable manpower to develop various new vaccines to temporarily alleviate the disaster caused by the epidemic. In addition to the development of vaccines, we need to also develop effective assessment methods to confirm vaccines’ efficacy and maximize the benefits that vaccines can bring. In addition to common evaluation methods, vaccine-specific and temporal expression of microRNAs have been shown to be related to vaccine efficacy or vaccine-associated diseases. In this article, we have introduced a microRNA-array-based approach, which could be potentially used for evaluating COVID-19 vaccine efficacy, specifically for pregnant women. As the mRNA in mRNA vaccines is decomposed by host cells within a few days, it is considered more suitable for pregnant women to utilize the method of vaccination during pregnancy. Moreover, pregnant women belong to a high-risk group for COVID-19, and there is currently no appropriate vaccine to newborns. Therefore, it’s important to find improved tools for evaluation of vaccine efficacy in response to the current situation caused by COVID-19.
AB - In order to solve COVID-19 pandemic, the entire world has invested considerable manpower to develop various new vaccines to temporarily alleviate the disaster caused by the epidemic. In addition to the development of vaccines, we need to also develop effective assessment methods to confirm vaccines’ efficacy and maximize the benefits that vaccines can bring. In addition to common evaluation methods, vaccine-specific and temporal expression of microRNAs have been shown to be related to vaccine efficacy or vaccine-associated diseases. In this article, we have introduced a microRNA-array-based approach, which could be potentially used for evaluating COVID-19 vaccine efficacy, specifically for pregnant women. As the mRNA in mRNA vaccines is decomposed by host cells within a few days, it is considered more suitable for pregnant women to utilize the method of vaccination during pregnancy. Moreover, pregnant women belong to a high-risk group for COVID-19, and there is currently no appropriate vaccine to newborns. Therefore, it’s important to find improved tools for evaluation of vaccine efficacy in response to the current situation caused by COVID-19.
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U2 - 10.3390/vaccines10101681
DO - 10.3390/vaccines10101681
M3 - Article
AN - SCOPUS:85140993201
SN - 2076-393X
VL - 10
JO - Vaccines
JF - Vaccines
IS - 10
M1 - 1681
ER -