@article{b5ba101607674b7ab23a556fcf4f6879,
title = "Uterine sarcoma part III—Targeted therapy: The Taiwan Association of Gynecology (TAG) systematic review",
abstract = "Uterine sarcoma is a very aggressive and highly lethal disease. Even after a comprehensive staging surgery or en block cytoreduction surgery followed by multimodality therapy (often chemotherapy and/or radiation therapy), many patients relapse or present with distant metastases, and finally die of diseases. The worst outcome of uterine sarcomas is partly because of their rarity, unknown etiology, and highly divergent genetic aberration. Uterine sarcomas are often classified into four distinct subtypes, including uterine leiomyosarcoma, low-grade uterine endometrial stromal sarcoma, high-grade uterine endometrial stromal sarcoma, and undifferentiated uterine sarcoma. Currently, evidence from tumor biology found that these tumors showed alternation and/or mutation of genomes and the intracellular signal pathway. In addition, some preclinical studies showed promising results for targeting receptor tyrosine kinase signaling, phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway, various kinds of growth factor pathways, Wnt/beta-catenin signaling pathway, transforming growth factor β/bone morphogenetic protein signal pathway, aurora kinase A, MDM2 proto-oncogene, histone deacetylases, sex hormone receptors, certain types of oncoproteins, and/or loss of tumor suppressor genes. The current review is attempted to summarize the recurrent advance of targeted therapy for uterine sarcomas.",
author = "{The Taiwan Association of Gynecology Systematic Review Group} and Yen, {Ming Shyen} and Chen, {Jen Ruei} and Wang, {Peng Hui} and Wen, {Kuo Chang} and Chen, {Yi Jen} and Ng, {Heung Tat} and Chang, {Yen Hou} and Yi Chang and Chao, {Hsiang Tai} and Chao, {Kuan Chong} and Chuang, {Chi Mu} and Ho, {Chi Hong} and Horng, {Huann Cheng} and Huang, {Chen Yu} and Jiang, {Ling Yu} and Liu, {Chia Hao} and Li, {Hsin Yang} and Sun, {Pi Lin} and Wu, {Hua Hsi} and Ju, {Fong Yuan} and Tsai, {Chih Ping} and Chang, {Wen Hsun} and Hsu, {Yen Mei} and Huang, {Shu Yun} and Lee, {Na Rong} and Chen, {Chih Yao} and Chang, {Wen Chun} and Chen, {Chii Hou} and Chen, {Ruey Jian} and Chow, {Song Nan} and Lien, {Yih Ron} and Sheu, {Bor Ching} and Torng, {Pao Ling} and Wei, {Lin Hung} and Yen, {Men Luh} and Lee, {Wen Ling} and Wang, {Kuan Chin} and Chang, {Chih Long} and Chen, {Chih Ping} and Chen, {Tze Chien} and Huang, {Jian Pei} and Huang, {Ming Chao} and Wang, {Yeou Lih} and Chang, {Cheng Chang} and Liu, {Jah Yao} and Su, {Her Young} and Wang, {Yu Chi} and Yu, {Mu Hsien} and Chu, {Ching Chuang} and Wu, {Meng Hsing}",
note = "Funding Information: This work was supported in part by a grant from the Ministry of Science and Technology, Executive Yuan ( MOST 103-2314-B-010-043-MY3 ), and by Taipei Veterans General Hospital ( V102C-141 , V103C-112 , V104C-095 , and V105C-096 ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding was received for this study. We also appreciate the Clinical Research Core Laboratory and the Medical Science & Technology Building of Taipei Veterans General Hospital for providing experimental space and facilities. Publisher Copyright: {\textcopyright} 2016",
year = "2016",
month = oct,
day = "1",
doi = "10.1016/j.tjog.2016.07.001",
language = "English",
volume = "55",
pages = "625--634",
journal = "Taiwanese Journal of Obstetrics and Gynecology",
issn = "1028-4559",
publisher = "Elsevier Taiwan LLC",
number = "5",
}