摘要
The UV-guided isolation of polyacetylenes from the crude extract of Codonopsis pilosula has successfully led to the characterization of five new polyynes, pilosulynes A-E (1-5), and two new polyenes, pilosulynes F and G (6 and 7), as well as five known analogues (8-12). Their structures were determined by spectroscopic methods, including ICD and 1D/2D NMR experiments. The absolute configurations of the 6,7-diol moiety of the isolated compounds were determined by the Snatzke's method, which revealed an induced circular dichroism after the addition of dimolybdenum tetraacetate in DMSO. Compound 6 exhibited anti-HCV activity in the HCVcc infection assay with an EC50 value of 47.2 μM.
原文 | English |
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頁(從 - 到) | 41324-41331 |
頁數 | 8 |
期刊 | RSC Advances |
卷 | 5 |
發行號 | 52 |
DOIs | |
出版狀態 | Published - 2015 |
All Science Journal Classification (ASJC) codes
- 化學 (全部)
- 化學工程 (全部)