Validation of Alcohol Flushing Questionnaire to Identify ALDH2 Status in a Case–Control Study of Head and Neck Cancer

研究成果: Review article

摘要

Background: Carriers of the ALDH2*2 allele have impaired alcohol metabolism and are more susceptible to the development of alcohol-related cancers, including head and neck cancer (HNC). Screening for ALDH2*2 allele may identify high-risk individuals for alcohol health education. Although genotyping of ALDH2 is the most accurate way to identify ALDH2 deficiency, it may not be practical due to the cost and requirement for genotyping service. Methods: This study evaluated the accuracy of the alcohol flushing questionnaire to identify ALDH2 deficiency in a case–control study of HNC conducted in Taiwan using data collected from 904 patients with HNC and 1,078 controls. Results: Overall, alcohol flushing questionnaire had a high sensitivity (89%) of identifying ALDH2*2 carriers among the control subjects and a good sensitivity (79%) among the patients with HNC. The sensitivity of the alcohol flushing questionnaire in identifying ALDH2*2 carriers was affected by alcohol use, with a lower sensitivity among individuals who consumed alcohol, particularly among current regular (drinking alcohol once per week or more) alcohol drinkers. Conclusions: The current validation study showed that the alcohol flushing questionnaire may be a reasonable method to identify ALDH2-deficient individuals. However, current regular users of alcohol who reported no alcohol flushing may need to undergo genotyping of ALDH2 for a more accurate assessment of the ALDH2 status.

原文English
頁(從 - 到)1225-1233
頁數9
期刊Alcoholism: Clinical and Experimental Research
43
發行號6
DOIs
出版狀態Published - 2019 六月 1

指紋

Head and Neck Neoplasms
Alcohols
Surveys and Questionnaires
Alleles
Validation Studies
Taiwan
Health Education
Alcohol Drinking
Metabolism
Screening
Education
Health
Costs and Cost Analysis

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

引用此文

@article{19f0315159384c07b6d92faa4a77e3e1,
title = "Validation of Alcohol Flushing Questionnaire to Identify ALDH2 Status in a Case–Control Study of Head and Neck Cancer",
abstract = "Background: Carriers of the ALDH2*2 allele have impaired alcohol metabolism and are more susceptible to the development of alcohol-related cancers, including head and neck cancer (HNC). Screening for ALDH2*2 allele may identify high-risk individuals for alcohol health education. Although genotyping of ALDH2 is the most accurate way to identify ALDH2 deficiency, it may not be practical due to the cost and requirement for genotyping service. Methods: This study evaluated the accuracy of the alcohol flushing questionnaire to identify ALDH2 deficiency in a case–control study of HNC conducted in Taiwan using data collected from 904 patients with HNC and 1,078 controls. Results: Overall, alcohol flushing questionnaire had a high sensitivity (89{\%}) of identifying ALDH2*2 carriers among the control subjects and a good sensitivity (79{\%}) among the patients with HNC. The sensitivity of the alcohol flushing questionnaire in identifying ALDH2*2 carriers was affected by alcohol use, with a lower sensitivity among individuals who consumed alcohol, particularly among current regular (drinking alcohol once per week or more) alcohol drinkers. Conclusions: The current validation study showed that the alcohol flushing questionnaire may be a reasonable method to identify ALDH2-deficient individuals. However, current regular users of alcohol who reported no alcohol flushing may need to undergo genotyping of ALDH2 for a more accurate assessment of the ALDH2 status.",
author = "Jenn-Ren Hsiao and Wei-Ting Lee and Chun-Yen Ou and Cheng-Chih Huang and Chan-Chi Chang and Sen-Tien Tsai and Ken-Chung Chen and Jehn-Shun Huang and Dung-Yau Wang and Yu-Hsuan Lai and Yuan-Hua Wu and Wei-Ting Hsueh and Shang-Yin Wu and Chia-Jui Yen and Jang-Yang Chang and Lin, {Chen Lin} and Weng, {Ya Ling} and Yang, {Han Chien} and Chen, {Yu Shan} and Chang, {Jeffrey S.}",
year = "2019",
month = "6",
day = "1",
doi = "10.1111/acer.14049",
language = "English",
volume = "43",
pages = "1225--1233",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Validation of Alcohol Flushing Questionnaire to Identify ALDH2 Status in a Case–Control Study of Head and Neck Cancer

AU - Hsiao, Jenn-Ren

AU - Lee, Wei-Ting

AU - Ou, Chun-Yen

AU - Huang, Cheng-Chih

AU - Chang, Chan-Chi

AU - Tsai, Sen-Tien

AU - Chen, Ken-Chung

AU - Huang, Jehn-Shun

AU - Wang, Dung-Yau

AU - Lai, Yu-Hsuan

AU - Wu, Yuan-Hua

AU - Hsueh, Wei-Ting

AU - Wu, Shang-Yin

AU - Yen, Chia-Jui

AU - Chang, Jang-Yang

AU - Lin, Chen Lin

AU - Weng, Ya Ling

AU - Yang, Han Chien

AU - Chen, Yu Shan

AU - Chang, Jeffrey S.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Background: Carriers of the ALDH2*2 allele have impaired alcohol metabolism and are more susceptible to the development of alcohol-related cancers, including head and neck cancer (HNC). Screening for ALDH2*2 allele may identify high-risk individuals for alcohol health education. Although genotyping of ALDH2 is the most accurate way to identify ALDH2 deficiency, it may not be practical due to the cost and requirement for genotyping service. Methods: This study evaluated the accuracy of the alcohol flushing questionnaire to identify ALDH2 deficiency in a case–control study of HNC conducted in Taiwan using data collected from 904 patients with HNC and 1,078 controls. Results: Overall, alcohol flushing questionnaire had a high sensitivity (89%) of identifying ALDH2*2 carriers among the control subjects and a good sensitivity (79%) among the patients with HNC. The sensitivity of the alcohol flushing questionnaire in identifying ALDH2*2 carriers was affected by alcohol use, with a lower sensitivity among individuals who consumed alcohol, particularly among current regular (drinking alcohol once per week or more) alcohol drinkers. Conclusions: The current validation study showed that the alcohol flushing questionnaire may be a reasonable method to identify ALDH2-deficient individuals. However, current regular users of alcohol who reported no alcohol flushing may need to undergo genotyping of ALDH2 for a more accurate assessment of the ALDH2 status.

AB - Background: Carriers of the ALDH2*2 allele have impaired alcohol metabolism and are more susceptible to the development of alcohol-related cancers, including head and neck cancer (HNC). Screening for ALDH2*2 allele may identify high-risk individuals for alcohol health education. Although genotyping of ALDH2 is the most accurate way to identify ALDH2 deficiency, it may not be practical due to the cost and requirement for genotyping service. Methods: This study evaluated the accuracy of the alcohol flushing questionnaire to identify ALDH2 deficiency in a case–control study of HNC conducted in Taiwan using data collected from 904 patients with HNC and 1,078 controls. Results: Overall, alcohol flushing questionnaire had a high sensitivity (89%) of identifying ALDH2*2 carriers among the control subjects and a good sensitivity (79%) among the patients with HNC. The sensitivity of the alcohol flushing questionnaire in identifying ALDH2*2 carriers was affected by alcohol use, with a lower sensitivity among individuals who consumed alcohol, particularly among current regular (drinking alcohol once per week or more) alcohol drinkers. Conclusions: The current validation study showed that the alcohol flushing questionnaire may be a reasonable method to identify ALDH2-deficient individuals. However, current regular users of alcohol who reported no alcohol flushing may need to undergo genotyping of ALDH2 for a more accurate assessment of the ALDH2 status.

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U2 - 10.1111/acer.14049

DO - 10.1111/acer.14049

M3 - Review article

C2 - 30977906

AN - SCOPUS:85065204359

VL - 43

SP - 1225

EP - 1233

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 6

ER -