Valproic acid suppresses the synaptic response mediated by the NMDA receptors in rat amygdalar slices

Po Wu Gean, Chiung Chun Huang, Chen Road Hung, Jing Jane Tsai

研究成果: Article同行評審

72 引文 斯高帕斯(Scopus)

摘要

The mechanism of action of the anticonvulsant drug valproic acid (VPA) was studied in rat amygdaloid slices using intracellular recording techniques. In the presence of hicuculline (20 μM), stimulation of the endopyriform nucleus evoked an excitatory postsynaptic potential (EPSP) followed by a paroxysmal depolarizing shift (PDS). Superfusion of VPA (2 mM) reversibly suppressed the PDS. Synaptic response mediated by the N-methyl-d-aspartate (NMDA) receptors (EPSPNMDA) was isolated pharmacologically by application of a solution containing nonNMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and gamma-aminobutyric acid receptor antagonist bicuculline (20 μM). VPA (0.2-10 mM) reversibly reduced the amplitude of the EPSPNMDA in a dose-dependent manner. Higher concentration of VPA (10 mM), in addition, suppressed the normal Synaptic transmission. These results suggest that VPA's anticonvulsant effect is due, at least in part, to its blocking action on the EPSPNMDA.

原文English
頁(從 - 到)333-336
頁數4
期刊Brain Research Bulletin
33
發行號3
DOIs
出版狀態Published - 1994

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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