TY - JOUR
T1 - Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections
AU - Yu, Victor L.
AU - Hansen, Dennis S.
AU - Wen, Chien Ko
AU - Sagnimeni, Asia
AU - Klugman, Keith P.
AU - Von Gottberg, Anne
AU - Goossens, Herman
AU - Wagener, Marilyn M.
AU - Benedi, Vicente J.
AU - Casellas, Jose Maria
AU - Trenholme, Gordon
AU - McCormack, Joseph
AU - Mohapatra, Sunita
AU - Mulazimoglu, Lutfiye
PY - 2007/7
Y1 - 2007/7
N2 - We studied 455 consecutive episodes of Klebsiella pneumoniae bacteremia occurring in 7 countries. Community-acquired pneumonia and an invasive syndrome of liver abscess, meningitis, or endophthalmitis occurred only in Taiwan and South Africa. Infections by K1 and K2 capsular serotype, the mucoid phenotype, and aerobactin production were important determinants of virulence. The mucoid phenotype was seen in 94% of isolates in patients with community-acquired pneumonia and in 100% of isolates that caused the invasive syndrome in Taiwan and South Africa, compared with only 2% of isolates elsewhere. Mortality of mice injected with mucoid strains (69%) was strikingly higher than that occurring in mice injected with nonmucoid strains (3%, p<0.001). Differences in clinical features of bacteremic infection with K. pneumoniae are due to the virulence factors expressed by the organism.
AB - We studied 455 consecutive episodes of Klebsiella pneumoniae bacteremia occurring in 7 countries. Community-acquired pneumonia and an invasive syndrome of liver abscess, meningitis, or endophthalmitis occurred only in Taiwan and South Africa. Infections by K1 and K2 capsular serotype, the mucoid phenotype, and aerobactin production were important determinants of virulence. The mucoid phenotype was seen in 94% of isolates in patients with community-acquired pneumonia and in 100% of isolates that caused the invasive syndrome in Taiwan and South Africa, compared with only 2% of isolates elsewhere. Mortality of mice injected with mucoid strains (69%) was strikingly higher than that occurring in mice injected with nonmucoid strains (3%, p<0.001). Differences in clinical features of bacteremic infection with K. pneumoniae are due to the virulence factors expressed by the organism.
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U2 - 10.3201/eid1307.070187
DO - 10.3201/eid1307.070187
M3 - Article
C2 - 18214169
AN - SCOPUS:34447270735
SN - 1080-6040
VL - 13
SP - 986
EP - 993
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 7
ER -