Vitamin C effect on mitoxantrone-induced cytotoxicity in human breast cancer cell lines

Eliana Guerriero, Angela Sorice, Francesca Capone, Virginia Napolitano, Giovanni Colonna, Gabriella Storti, Giuseppe Castello, Susan Costantini, Ying Jan Wang

研究成果: Article同行評審

39 引文 斯高帕斯(Scopus)

摘要

In recent years the use of natural dietary antioxidants to minimize the cytotoxicity and the damage induced in normal tissues by antitumor agents is gaining consideration. In literature, it is reported that vitamin C exhibits some degree of antineoplastic activity whereas Mitoxantrone (MTZ) is a synthetic anti-cancer drug with significant clinical effectiveness in the treatment of human malignancies but with severe side effects. Therefore, we have investigated the effect of vitamin C alone or combined with MTZ on MDA-MB231 and MCF7 human breast cancer cell lines to analyze their dose-effect on the tumor cellular growth, cellular death, cell cycle and cell signaling. Our results have evidenced that there is a dosedependence on the inhibition of the breast carcinoma cell lines, MCF7 and MDAMB231, treated with vitamin C and MTZ. Moreover, their combination induces: i) a cytotoxic effect by apoptotic death, ii) a mild G2/M elongation and iii) H2AX and mild PI3K activation. Hence, the formulation of vitamin C with MTZ induces a higher cytotoxicity level on tumor cells compared to a disjointed treatment. We have also found that the vitamin C enhances the MTZ effect allowing the utilization of lower chemotherapic concentrations in comparison to the single treatments.

原文English
文章編號e115287
期刊PloS one
9
發行號12
DOIs
出版狀態Published - 2014 十二月 22

All Science Journal Classification (ASJC) codes

  • 多學科

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