TY - GEN
T1 - Voltammetric approach for in-vivo detecting dopamine level of rat's brain
AU - Chen, G. C.
AU - Han, H. Z.
AU - Tsai, T. C.
AU - Cheng, C. C.
AU - Jason Chen, J. J.
PY - 2011
Y1 - 2011
N2 - Parkinson's disease (PD) is caused by insufficient release of dopamine (DA). Knowing the DA level of animal's brain could provide a direct evidence for evaluating novel treatments for PD, especially in the acute or long-term studies. In this study, we used nanogold particle surface modified platinum electrodes to measure DA using cyclic voltammetry and amperometry technique for in-vitro DA sensing. For in-vivo study, deep brain stimulation (DBS) was applied to increase DA release as a validation step for in-vivo DA detection using amperometry technique. For the future application of in-vivo DA sensing in freely moving animal, miniaturization of the system which can be incorporated to a radio frequency transmitter is essential. Our ultimate goal is to apply the wireless miniature DA sensing unit for in-vivo DA recording as a direct evident and evaluation tool for novel treatment such as repetitive transcranial magnetic stimulation (rTMS) treatment for PD animal study.
AB - Parkinson's disease (PD) is caused by insufficient release of dopamine (DA). Knowing the DA level of animal's brain could provide a direct evidence for evaluating novel treatments for PD, especially in the acute or long-term studies. In this study, we used nanogold particle surface modified platinum electrodes to measure DA using cyclic voltammetry and amperometry technique for in-vitro DA sensing. For in-vivo study, deep brain stimulation (DBS) was applied to increase DA release as a validation step for in-vivo DA detection using amperometry technique. For the future application of in-vivo DA sensing in freely moving animal, miniaturization of the system which can be incorporated to a radio frequency transmitter is essential. Our ultimate goal is to apply the wireless miniature DA sensing unit for in-vivo DA recording as a direct evident and evaluation tool for novel treatment such as repetitive transcranial magnetic stimulation (rTMS) treatment for PD animal study.
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U2 - 10.1007/978-3-642-21729-6_95
DO - 10.1007/978-3-642-21729-6_95
M3 - Conference contribution
AN - SCOPUS:79960028256
SN - 9783642217289
T3 - IFMBE Proceedings
SP - 367
EP - 370
BT - 5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011
T2 - 5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011
Y2 - 20 June 2011 through 23 June 2011
ER -