Water-based synthesis and processing of novel biodegradable elastomers for medical applications

Shan Hui Hsu, Kun Che Hung, Ying Yi Lin, Chiu Hun Su, Hsi Yi Yeh, U. Ser Jeng, Chun Yi Lu, Shenghong A. Dai, Wei En Fu, Jui Che Lin

研究成果: Article同行評審

67 引文 斯高帕斯(Scopus)

摘要

Biodegradable elastomers in the form of polyurethane nanoparticles (NPs) were successfully synthesized based on the combinations of two hydrolysis-prone polyester diols by a green water-based process. The anionic nature of the polymers successfully rendered polyurethane NPs (30-50 nm) consisting of approximately 200-300 polymer chains. The mechanical properties and degradation rate could be adjusted by the types and ratios of the component oligodiols in the soft segment. We demonstrated the feasibility using these biodegradable NPs as building blocks to generate self-assembled morphologies in nanometric, micrometric, or bulk scale, bearing excellent elasticity and biocompatibility. The elastic NPs and their various assembled forms represent a series of smart biodegradable elastomers with potential medical applications.

原文English
頁(從 - 到)5083-5092
頁數10
期刊Journal of Materials Chemistry B
2
發行號31
DOIs
出版狀態Published - 2014 8月 21

All Science Journal Classification (ASJC) codes

  • 化學 (全部)
  • 生物醫學工程
  • 材料科學(全部)

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