Water-Immersible MEMS scanning mirror designed for wide-field fast-scanning photoacoustic microscopy

Junjie Yao, Chih Hsien Huang, Catherine Martel, Konstantin I. Maslov, Lidai Wang, Joon Mo Yang, Liang Gao, Gwendalyn Randolph, Jun Zou, Lihong V. Wang

研究成果: Conference contribution

摘要

By offering images with high spatial resolution and unique optical absorption contrast, optical-resolution photoacoustic microscopy (OR-PAM) has gained increasing attention in biomedical research. Recent developments in OR-PAM have improved its imaging speed, but have sacrificed either the detection sensitivity or field of view or both. We have developed a wide-field fast-scanning OR-PAM by using a water-immersible MEMS scanning mirror (MEMS-ORPAM). Made of silicon with a gold coating, the MEMS mirror plate can reflect both optical and acoustic beams. Because it uses an electromagnetic driving force, the whole MEMS scanning system can be submerged in water. In MEMS-ORPAM, the optical and acoustic beams are confocally configured and simultaneously steered, which ensures uniform detection sensitivity. A B-scan imaging speed as high as 400 Hz can be achieved over a 3 mm scanning range. A diffraction-limited lateral resolution of 2.4 μm in water and a maximum imaging depth of 1.1 mm in soft tissue have been experimentally determined. Using the system, we imaged the flow dynamics of both red blood cells and carbon particles in a mouse ear in vivo. By using Evans blue dye as the contrast agent, we also imaged the flow dynamics of lymphatic vessels in a mouse tail in vivo. The results show that MEMS-OR-PAM could be a powerful tool for studying highly dynamic and time-sensitive biological phenomena.

原文English
主出版物標題Photons Plus Ultrasound
主出版物子標題Imaging and Sensing 2013
DOIs
出版狀態Published - 2013
事件Photons Plus Ultrasound: Imaging and Sensing 2013 - San Francisco, CA, United States
持續時間: 2013 二月 32013 二月 5

出版系列

名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE
8581
ISSN(列印)1605-7422

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2013
國家United States
城市San Francisco, CA
期間13-02-0313-02-05

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • 引用此

    Yao, J., Huang, C. H., Martel, C., Maslov, K. I., Wang, L., Yang, J. M., Gao, L., Randolph, G., Zou, J., & Wang, L. V. (2013). Water-Immersible MEMS scanning mirror designed for wide-field fast-scanning photoacoustic microscopy. 於 Photons Plus Ultrasound: Imaging and Sensing 2013 [858127] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; 卷 8581). https://doi.org/10.1117/12.2005669