## 摘要

Background: Coronary artery (CA) Z-score system is widely used to define CA aneurysm (CAA). Children and adolescents after acute stage of Kawasaki disease (KD-CA) have a higher risk of developing CAAs if their CA Z-score ≥ 2.5. Z-score system of peak oxygen consumption (Peak VO_{2} Z-score) allows comparisons across ages and sex, regardless of body size and puberty. We aimed to compare the exercise capacity (EC) indicated by peak VO_{2} Z-score during cardiopulmonary exercise testing (CPET) directly between KD-CA with different CA Z-score. Methods: KD-CA after acute stage who received CPET in the last 5 years were retrospectively recruited. CA Z-score was based on Lambda-Mu-Sigma method. Max-Z was the maximum CA Z-score of different CAs. KD children with Max-Z < 2.5 and ≥ 2.5 were defined as KD-1 and KD-2 groups, respectively. Peak VO_{2} Z-score was calculated using the equation established based on Hong Kong Chinese children and adolescent database. Results: One hundred two KD-CA were recruited (mean age: 11.71 ± 2.57 years). The mean percent of measured peak VO_{2} to predicted value (peak PD%) was 90.11 ± 13.33. All basic characteristics and baseline pulmonary function indices were comparable between KD-1 (n = 87) and KD-2 (n = 15). KD-1 had significantly higher peak VO_{2} Z-score (p =.025), peak PD% (p =.008), peak metabolic equivalent (p =.027), and peak rate pressure product (p =.036) than KD-2. Conclusions: KD-CA had slightly reduced EC than healthy peers. KD-CA with Max-Z ≥ 2.5 had significantly lower peak EC than those < 2.5. Max-Z is potentially useful follow-up indicator after acute stage of KD.

原文 | English |
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文章編號 | 129 |

期刊 | Italian Journal of Pediatrics |

卷 | 49 |

發行號 | 1 |

DOIs | |

出版狀態 | Published - 2023 12月 |

## All Science Journal Classification (ASJC) codes

- 兒科、圍產兒和兒童健康