Which demographic variables are necessary to correct in neuroimaging studies of serotonin transporter availability? A SPECT study with [123I]ADAM

研究成果: Article

3 引文 斯高帕斯(Scopus)

摘要

Previous studies have shown that many demographic variables influence serotonin transporter (SERT) availability as assessed by single photon emission computed tomography (SPECT). The aim of this study was to explore which demographic variables influenced the SERT availability most in a SPECT study with [123I]ADAM. Ninety-five healthy volunteers were recruited. Age, sex, smoking, alcohol intake, educational level, body mass index, seasonal change, and SERT availability were recorded and then analyzed by multivariate linear regression. Age was the only variable that was significantly associated with SERT availability (calculate: (midbrain-cerebellum)/cerebellum). Furthermore, the inverse correlation of age and SERT availability may be present only before the age of 47. Age should be a covariate in SERT-related neuroimaging analyses, particularly in participants under the age of 47 years.

原文English
頁(從 - 到)320-324
頁數5
期刊Psychiatry Research - Neuroimaging
231
發行號3
DOIs
出版狀態Published - 2015 三月 30

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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