Wide-field fast-scanning photoacoustic microscopy based on a water-immersible MEMS scanning mirror

Junjie Yao, Chih Hsien Huang, Lidai Wang, Joon Mo Yang, Liang Gao, Konstantin I. Maslov, Jun Zou, Lihong V. Wang

研究成果: Article同行評審

119 引文 斯高帕斯(Scopus)

摘要

By offering images with high spatial resolution and unique optical absorption contrast, optical-resolution photoacoustic microscopy (OR-PAM) has gained increasing attention in biomedical research. Recent developments in OR-PAM have improved its imaging speed, but have to sacrifice either the detection sensitivity or field of view or both. We have developed a wide-field fast-scanning ORPAM by using a water-immersible microelectromechanical systems (MEMS) scanning mirror (MEMS-OR-PAM). In MEMS-OR-PAM, the optical and acoustic beams are confocally configured and simultaneously steered, which ensures the uniform detection sensitivity. A B-scan imaging speed as high as 400 Hz can be achieved over a 3 mm scanning range. Using the system, we imaged the flow dynamics of both red blood cells and carbon particles in a mouse ear in vivo. Presented results show that MEMS-OR-PAM could be a powerful tool for studying highly dynamic and time-sensitive biological phenomena.

原文English
文章編號080505
期刊Journal of Biomedical Optics
17
發行號8
DOIs
出版狀態Published - 2012 8月

All Science Journal Classification (ASJC) codes

  • 電子、光磁材料
  • 生物材料
  • 原子與分子物理與光學
  • 生物醫學工程

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