TY - JOUR
T1 - X-ray microbeams
T2 - Proceedings of the 4th International Worhshop on Medical Applications of Synchrotron Radiation MASR 2004
AU - Dilmanian, F. A.
AU - Qu, Y.
AU - Liu, S.
AU - Cool, C. D.
AU - Gilbert, J.
AU - Hainfeld, J. F.
AU - Kruse, C. A.
AU - Laterra, J.
AU - Lenihan, D.
AU - Nawrocky, M. M.
AU - Pappas, G.
AU - Sze, C. I.
AU - Yuasa, T.
AU - Zhong, N.
AU - Zhong, Z.
AU - McDonald, J. W.
N1 - Funding Information:
We thank T. Bacarian, M.E. Berens, A. Feldman, C. Garibotto, T. George, J. Giordano, S. Hussain, Z. Hussain, Y. Kublanskaya, S. Leroy, R. Maehara, P. Mortazavi, A. Nithi, I. Orion, S. Rafiq, B. Ren, E.S. Rosenzweig, J.K. Robinson, A. Ruvinskaya, T. Steidinger, S. Thomas, J. Welwart, D. Williams, A.D. Woodhead, and R. Yakupov for their valuable assistance. These studies were funded by the Nextsteps Foundation, IL (JWM), the National Institute of Health NINDS grants NS37927, NS40520, NS39577 (JWM) and NS43231 (FAD), and the Office of Biological and Environmental Research, U.S. Department of Energy. This research was carried out at the NSLS which is supported by the U.S. Department of Energy, Division of Materials Sciences and Division of Chemical Sciences, under Contract No. DE-AC02-98CH10886.
PY - 2005/8/11
Y1 - 2005/8/11
N2 - Irradiation with parallel arrays of thin, planar slices of X-ray beams (microplanar beams, or microbeams) spares normal tissue, including the central nervous system (CNS), and preferentially damages tumors. The effects are mediated, at least in part, by the tissue's microvasculature that seems to effectively repair itself in normal tissue but fails to do so in tumors. Consequently, the therapeutic index of single-fraction unidirectional microbeam irradiations has been shown to be larger than that of single-fraction unidirectional unsegmented beams in treating the intracranial rat 9L gliosarcoma tumor model (9LGS) and the subcutaneous murine mammary carcinoma EMT-6. This paper presents results demonstrating that individual microbeams, or arrays of parallel ones, can also be used for targeted, selective cell ablation in the CNS, and also to induce demyelination. The results highlight the value of the method as a powerful tool for studying the CNS through selective cell ablation, besides its potential as a treatment modality in clinical oncology.
AB - Irradiation with parallel arrays of thin, planar slices of X-ray beams (microplanar beams, or microbeams) spares normal tissue, including the central nervous system (CNS), and preferentially damages tumors. The effects are mediated, at least in part, by the tissue's microvasculature that seems to effectively repair itself in normal tissue but fails to do so in tumors. Consequently, the therapeutic index of single-fraction unidirectional microbeam irradiations has been shown to be larger than that of single-fraction unidirectional unsegmented beams in treating the intracranial rat 9L gliosarcoma tumor model (9LGS) and the subcutaneous murine mammary carcinoma EMT-6. This paper presents results demonstrating that individual microbeams, or arrays of parallel ones, can also be used for targeted, selective cell ablation in the CNS, and also to induce demyelination. The results highlight the value of the method as a powerful tool for studying the CNS through selective cell ablation, besides its potential as a treatment modality in clinical oncology.
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U2 - 10.1016/j.nima.2005.03.062
DO - 10.1016/j.nima.2005.03.062
M3 - Conference article
AN - SCOPUS:23144441479
SN - 0168-9002
VL - 548
SP - 30
EP - 37
JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
IS - 1-2
Y2 - 23 September 2005 through 25 September 2005
ER -