Zero-valent iron based nanoparticles selectively inhibit cancerous cells through mitochondria-mediated autophagy

Dar-Bin Shieh, Li Xing Yang, Wei Ting Lee, Kuang Jing Huang, Ya Na Wu, Wu-Chou Su, Dong-Hwang Chen, Benjamin Tsang

研究成果: Conference contribution

2 引文 (Scopus)

摘要

How to improve the selectivity and efficacy of anticancer agents and to reduce side effects has always been a big challenge in clinical cancer therapy. Chemotherapeutic agents are usually toxic to both cancer and normal tissues, thus rendering compromised overall clinical outcome. Here we developed zero-valent iron nanoparticles (ZVI NPs) that exhibited selectivity toward higher toxicity to most cancerous cells thus opening a new era of anti-cancer therapy or adjuvant therapy through a novel molecular signaling pathway. We used head-and-neck cancer (HNC) cells and ovarian cancer (OVCA) cells to test the anti-cancer properties of ZVI NPs. The ZVI NPs served as a strong reactive oxygen species (ROS) inducer and caused irreversible mitochondria membrane potential lost in sensitive cancer cells that lead to cancer cell autophagy and growth suppression, while not significantly affect normal cell population. Further, the cytotoxicity of the ZVI NPs is highly depended on its redox state as oxidation of the NPs upon aging reduced their cytotoxic potency. In vivo study revealed a dose dependent tumor size reduction in tumor-bearing mice model without significant weight loss and pathological signs. These results suggest that ZVI NPs may serve as a new class of anticancer agent for a wide spectra of neoplastic diseases.

原文English
主出版物標題2017 IEEE 17th International Conference on Nanotechnology, NANO 2017
發行者Institute of Electrical and Electronics Engineers Inc.
頁面168-170
頁數3
ISBN(電子)9781509030286
DOIs
出版狀態Published - 2017 十一月 21
事件17th IEEE International Conference on Nanotechnology, NANO 2017 - Pittsburgh, United States
持續時間: 2017 七月 252017 七月 28

出版系列

名字2017 IEEE 17th International Conference on Nanotechnology, NANO 2017

Other

Other17th IEEE International Conference on Nanotechnology, NANO 2017
國家United States
城市Pittsburgh
期間17-07-2517-07-28

指紋

Mitochondria
Iron
Cells
Nanoparticles
Antineoplastic Agents
Tumors
Bearings (structural)
Poisons
Cytotoxicity
Toxicity
Reactive Oxygen Species
Aging of materials
Tissue
Membranes
Oxidation
Oxygen

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Electrical and Electronic Engineering

引用此文

Shieh, D-B., Yang, L. X., Lee, W. T., Huang, K. J., Wu, Y. N., Su, W-C., ... Tsang, B. (2017). Zero-valent iron based nanoparticles selectively inhibit cancerous cells through mitochondria-mediated autophagy. 於 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017 (頁 168-170). [8117431] (2017 IEEE 17th International Conference on Nanotechnology, NANO 2017). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NANO.2017.8117431
Shieh, Dar-Bin ; Yang, Li Xing ; Lee, Wei Ting ; Huang, Kuang Jing ; Wu, Ya Na ; Su, Wu-Chou ; Chen, Dong-Hwang ; Tsang, Benjamin. / Zero-valent iron based nanoparticles selectively inhibit cancerous cells through mitochondria-mediated autophagy. 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017. Institute of Electrical and Electronics Engineers Inc., 2017. 頁 168-170 (2017 IEEE 17th International Conference on Nanotechnology, NANO 2017).
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abstract = "How to improve the selectivity and efficacy of anticancer agents and to reduce side effects has always been a big challenge in clinical cancer therapy. Chemotherapeutic agents are usually toxic to both cancer and normal tissues, thus rendering compromised overall clinical outcome. Here we developed zero-valent iron nanoparticles (ZVI NPs) that exhibited selectivity toward higher toxicity to most cancerous cells thus opening a new era of anti-cancer therapy or adjuvant therapy through a novel molecular signaling pathway. We used head-and-neck cancer (HNC) cells and ovarian cancer (OVCA) cells to test the anti-cancer properties of ZVI NPs. The ZVI NPs served as a strong reactive oxygen species (ROS) inducer and caused irreversible mitochondria membrane potential lost in sensitive cancer cells that lead to cancer cell autophagy and growth suppression, while not significantly affect normal cell population. Further, the cytotoxicity of the ZVI NPs is highly depended on its redox state as oxidation of the NPs upon aging reduced their cytotoxic potency. In vivo study revealed a dose dependent tumor size reduction in tumor-bearing mice model without significant weight loss and pathological signs. These results suggest that ZVI NPs may serve as a new class of anticancer agent for a wide spectra of neoplastic diseases.",
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Shieh, D-B, Yang, LX, Lee, WT, Huang, KJ, Wu, YN, Su, W-C, Chen, D-H & Tsang, B 2017, Zero-valent iron based nanoparticles selectively inhibit cancerous cells through mitochondria-mediated autophagy. 於 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017., 8117431, 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017, Institute of Electrical and Electronics Engineers Inc., 頁 168-170, 17th IEEE International Conference on Nanotechnology, NANO 2017, Pittsburgh, United States, 17-07-25. https://doi.org/10.1109/NANO.2017.8117431

Zero-valent iron based nanoparticles selectively inhibit cancerous cells through mitochondria-mediated autophagy. / Shieh, Dar-Bin; Yang, Li Xing; Lee, Wei Ting; Huang, Kuang Jing; Wu, Ya Na; Su, Wu-Chou; Chen, Dong-Hwang; Tsang, Benjamin.

2017 IEEE 17th International Conference on Nanotechnology, NANO 2017. Institute of Electrical and Electronics Engineers Inc., 2017. p. 168-170 8117431 (2017 IEEE 17th International Conference on Nanotechnology, NANO 2017).

研究成果: Conference contribution

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T1 - Zero-valent iron based nanoparticles selectively inhibit cancerous cells through mitochondria-mediated autophagy

AU - Shieh, Dar-Bin

AU - Yang, Li Xing

AU - Lee, Wei Ting

AU - Huang, Kuang Jing

AU - Wu, Ya Na

AU - Su, Wu-Chou

AU - Chen, Dong-Hwang

AU - Tsang, Benjamin

PY - 2017/11/21

Y1 - 2017/11/21

N2 - How to improve the selectivity and efficacy of anticancer agents and to reduce side effects has always been a big challenge in clinical cancer therapy. Chemotherapeutic agents are usually toxic to both cancer and normal tissues, thus rendering compromised overall clinical outcome. Here we developed zero-valent iron nanoparticles (ZVI NPs) that exhibited selectivity toward higher toxicity to most cancerous cells thus opening a new era of anti-cancer therapy or adjuvant therapy through a novel molecular signaling pathway. We used head-and-neck cancer (HNC) cells and ovarian cancer (OVCA) cells to test the anti-cancer properties of ZVI NPs. The ZVI NPs served as a strong reactive oxygen species (ROS) inducer and caused irreversible mitochondria membrane potential lost in sensitive cancer cells that lead to cancer cell autophagy and growth suppression, while not significantly affect normal cell population. Further, the cytotoxicity of the ZVI NPs is highly depended on its redox state as oxidation of the NPs upon aging reduced their cytotoxic potency. In vivo study revealed a dose dependent tumor size reduction in tumor-bearing mice model without significant weight loss and pathological signs. These results suggest that ZVI NPs may serve as a new class of anticancer agent for a wide spectra of neoplastic diseases.

AB - How to improve the selectivity and efficacy of anticancer agents and to reduce side effects has always been a big challenge in clinical cancer therapy. Chemotherapeutic agents are usually toxic to both cancer and normal tissues, thus rendering compromised overall clinical outcome. Here we developed zero-valent iron nanoparticles (ZVI NPs) that exhibited selectivity toward higher toxicity to most cancerous cells thus opening a new era of anti-cancer therapy or adjuvant therapy through a novel molecular signaling pathway. We used head-and-neck cancer (HNC) cells and ovarian cancer (OVCA) cells to test the anti-cancer properties of ZVI NPs. The ZVI NPs served as a strong reactive oxygen species (ROS) inducer and caused irreversible mitochondria membrane potential lost in sensitive cancer cells that lead to cancer cell autophagy and growth suppression, while not significantly affect normal cell population. Further, the cytotoxicity of the ZVI NPs is highly depended on its redox state as oxidation of the NPs upon aging reduced their cytotoxic potency. In vivo study revealed a dose dependent tumor size reduction in tumor-bearing mice model without significant weight loss and pathological signs. These results suggest that ZVI NPs may serve as a new class of anticancer agent for a wide spectra of neoplastic diseases.

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M3 - Conference contribution

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T3 - 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017

SP - 168

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BT - 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017

PB - Institute of Electrical and Electronics Engineers Inc.

ER -

Shieh D-B, Yang LX, Lee WT, Huang KJ, Wu YN, Su W-C 等. Zero-valent iron based nanoparticles selectively inhibit cancerous cells through mitochondria-mediated autophagy. 於 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017. Institute of Electrical and Electronics Engineers Inc. 2017. p. 168-170. 8117431. (2017 IEEE 17th International Conference on Nanotechnology, NANO 2017). https://doi.org/10.1109/NANO.2017.8117431