Zonisamide at clinically relevant concentrations inhibits field EPSP but not presynaptic fiber volley in rat frontal cortex

Chin Wei Huang, Shinya Ueno, Motohiro Okada, Sunao Kaneko

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)

摘要

We investigated the effect of Zonisamide (ZNS), a newer anti-epileptic drug, on field potentials and neuropropagation in rat frontal cortex, with the aid of the 64-channel multi-electrode dish (MED64) system. The amplitude and propagation of field potentials were expressed dimensionally in the MED64 system. ZNS (3-100 μM) inhibited the amplitude and propagation of field excitatory postsynaptic potentials (fEPSP) in a concentration dependent manner. In contrast, ZNS could not suppress the amplitude and propagation of the presynaptic fiber volley (PrV) at clinically relevant concentrations (10-30 μM). Stimulating dependency with reduction fEPSP was seen in the presence of ZNS at clinically relevant concentrations, but not with PrV. The reduction of fEPSP amplitude was not accompanied by a change in paired-pulse facilitation. These data suggest that at clinically relevant concentrations of ZNS, the suppression of neuronal propagation is at least partially due to the postsynaptic mechanism, probably through α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA) receptors.

原文English
頁(從 - 到)51-60
頁數10
期刊Epilepsy Research
67
發行號1-2
DOIs
出版狀態Published - 2005 10月

All Science Journal Classification (ASJC) codes

  • 神經內科
  • 神經病學(臨床)

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