Zwitterionic polypeptides bearing carboxybetaine and sulfobetaine: Synthesis, self-assembly, and their interactions with proteins

Yu Lin Tsai, Yu Chao Tseng, Yan Miao Chen, Tain Ching Wen, Jeng Shiung Jan

研究成果: Article同行評審

22 引文 斯高帕斯(Scopus)

摘要

We report the synthesis of zwitterionic homopolypeptides and block copolypeptides bearing carboxybetaine and sulfobetaine (CB and SB) via combining γ-propargyl-l-glutamate NCA polymerization with efficient Huisgen's click reaction. The zwitterionic homopolypeptides adopted versatile chain conformations upon varying the solution pH, depending on the chain length and functional group. The zwitterionic homopolypeptides with a degree of polymerization (DP) of 60 adopted stable α-helical conformation due to their elongated side-chain, whereas the short ones (DP = 20) adopted different conformations at varying solution pH. Their interactions with proteins depend on the chain conformation and zwitterionic group. The short one bearing SB exhibited very low interactions with lysozyme and myoglobin due to its coil and zwitterionic nature. A preliminary study showed that the zwitterionic block copolypeptides self-assemble to form vesicles with tunable molecular packing and solution behavior. These biodegradable/biocompatible, zwitterionic polypeptides may be promising materials in many applications such as non-fouling coatings and drug delivery.

原文English
頁(從 - 到)1178-1189
頁數12
期刊Polymer Chemistry
9
發行號10
DOIs
出版狀態Published - 2018 3月 14

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 聚合物和塑料
  • 生物化學
  • 有機化學

指紋

深入研究「Zwitterionic polypeptides bearing carboxybetaine and sulfobetaine: Synthesis, self-assembly, and their interactions with proteins」主題。共同形成了獨特的指紋。

引用此