Effects of functional food sesame seed ingredients on health: inflammation and cancer

摘要

Sesame seed is an important crop used as food from ancient times Sesame seeds are rich in oil lignan and protein/amino acid It is reported that sesame seeds possess anti-oxidative and anti-inflammatory properties and are beneficial to recovery for cancer patients The functional ingredients may protect against inflammation-induced organ injury and affect cancer development Therefore the aims of the study are to investigate the effects of sesamol on (1) lipopolysaccharide (LPS)-induced inflammatory lung injury and cerulein-induced acute pancreatitis in rats and (2) the effects of cysteine on melanoma growth In the first part of the study sesamol inhibited pulmonary inflammatory injury reduced cell infiltration and protein leakage in bronchoalveolar lavage fluid (BALF) and decreased tumor necrosis factor (TNF)-a and nitric oxide production in both BALF and lung tissue in LPS-treated rats Sesamol also reduced inflammation in pancreatitis rats Furthermore sesamol decreased pro-inflammatory mediators TNF-a interleukin-1b nitric oxide and iNOS protein expressions and inhibited the nuclear factor (NF)-kB activation in LPS-activated macrophages It is suggested that sesamol protects inflammatory injury by inhibiting macrophage pro-inflammatory mediator productions through blocking the NF-kB pathway at least partially In the second part of the present study cysteine inhibited melanoma proliferation delayed cell cycle progression and induced melanoma senescence Cysteine activated the p21–p53 pathway and inhibited microphthalmia-associated transcription factor (MiTF) activation Cysteine changed the morphology and cytoskeleton structure significantly decreased intracellular calcium levels and increased hydrogen sulfide levels in melanoma In addition cysteine significantly decelerated the growing speed of melanoma tumor in mice It is suggested that cysteine decelerates melanoma growth by regulating proliferation through inducing MiTF-p21-p53 pathway-related senescence and hydrogen sulfide-associated microtubule destabilization at least partially In summary functional food sesame seeds-related ingredients sesamol and cysteine possess anti-inflammatory and anti-cancer properties which may be beneficial to inflammatory disease and cancer patients However more investigations will be needed

獎項日期	2015 12月 30
原文	English
監督員	Ming-Yi Liu (Supervisor)