Efficacy and Mechanism of Sesame Oil on Chronic Kidney Disease-induced Cardiac Hypertrophy

摘要

Chronic kidney disease (CKD) causes a progressive and irreversible loss of renal function Oxidative stress and fibrosis are highly related to the progression of CKD Hypokalemia and hypertension in CKD patients are common manifestation of preclinical cardiovascular conditions that have a predictive value for cardiovascular morbidity and mortality Left ventricular hypertrophy (LVH) an important risk factor in heart failure is attributed to long-term hypokalemia and hypertension in CKD The renin-angiotensin system (RAS) is involved in the development of LVH by which increases cardiac morbidity and mortality Activation of mitogen-activated protein kinases (MAPKs) and oxidative stress are important in RAS-mediated cardiac hypertrophy Sesame oil a natural nutrient-rich and potent antioxidant protects the kidney in many renal disorders and possesses potent anti-hypertensive activities We examined the efficacy and mechanism of sesame oil on cardiac hypertrophy in CKD We induced LVH using a CKD model by subcutaneously injecting deoxycorticosterone acetate (DOCA; 15 mg/ml/kg in mineral oil; twice weekly for 5 weeks) and supplementing with 1% sodium chloride drinking water (DOCA/salt) to uni-nephrectomized rats Sesame oil was gavaged (0 5 or 1 ml/kg/day for 7 days) after 4 weeks of DOCA/salt treatment Sesame oil significantly decreased blood urea nitrogen creatinine urine volume and albuminuria in DOCA/salt-treated rats Sesame oil significantly decreased renal hydroxyl radical peroxynitrite level lipid peroxidation osteopontin and collagen deposition but increased creatinine clearance rate and nuclear Nrf2 expression in DOCA/salt-treated rats In addition sesame oil effectively reduced the SP/DP and ECG abnormality the heart mass the thickness of left ventricle and the size of cardiomyocytes and increased the serum levels of K+ and Mg2+ in DOCA/salt-treated rats Furthermore sesame oil significantly decreased the levels of cardiac RAS oxidative stress and down-regulated the expression of MAPKs in DOCA/salt-treated rats We conclude that sesame oil mitigates renal dysfunction by inhibiting renal oxidative stress and fibrosis; attenuates LVH by regulating hypokalemia and decreasing cardiac RAS-mediated MAPK activation in CKD rats

獎項日期	2015 12月 31
原文	English
監督員	Ming-Yi Liu (Supervisor)