Enhanced photon energy conversion of iron oxide nanomaterials via ligand-to-metal charge transfer process for photothermal antibacterial activity and combined phototherapy

論文翻譯標題: 藉由配位子-金屬電荷轉移躍遷提升氧化鐵奈米材料光子能量轉換用於光熱抗菌以及複合性癌症光療法
  • 柯 翰

學生論文: Master's Thesis


The photon absorption enhancement inducing photothermal conversion via interfacial ligand-to-metal charge transfer (LMCT) was first proposed in this study Through a wet-chemistry hydrothermal process of tannic acid (TNA) and commercial iron oxide (γ-Fe2O3) nanoparticles (γ-IONP(c)) the phase transformation from γ-Fe2O3 to form Fe3O4 material UV-visible FT-IR and TGA measurements determined 6 1 % TNA molecules immobilized onto the surface of IONPs (IONP-TNA) Such ligand-assisted complex effect showed an absorption enhancement in the wide visible-NIR wavelengths via interfacial LMCT effect between TNA and IONPs The different TNA concentrations and reaction temperatures were further studied for demonstrating the preferred co-precipitation and self-assembly of TNA with Fe3+ ions on the NPs surface IONP-TNA was further modified with d-mannose (IONP-TNA@Man) to increase binding affinity toward the membrane molecules of Escherichia coli (E coli) IONP-TNA@Man could efficiently accumulate on the different strains of E coli and produce the localized hyperthermia to destroy the bacteria surface directly upon an excitation with a NIR laser It also sterilized well against Gram-positive bacteria as the model of Staphylococcus aureus (S aureus) Considering of eco-friendly concept IONP-TNA@Man could recycle via external magnetic field-integrated PTA treatment We prepared methylene blue (MB)-immobilized IONP-TNA (IONP-TNA@MB) for executing combined photothermal-photodynamic therapy (PDT) IONP-TNA@MB was stable in different environment and could deplete the glutathione (GSH) a natural PDT physiological barrier As an employment of 660 nm light IONP-TNA@MB acted as a therapeutic nano-mediator for inducing cancer cell death via the iron oxide-mediated phototherapy
獎項日期2018 七月 19
監督員Chih-Chia Huang (Supervisor)