Identification of agonist and antagonist activities of glucocorticoid and mineralocorticoid receptors in Taiwanese rivers using bioassays and LC-MS/MS

論文翻譯標題: 利用生物試驗及液相層析串聯式質譜儀檢測臺灣河川中之類(抗)糖皮質激素及類(抗)鹽皮質激素
  • 李 宗益

學生論文: Master's Thesis

摘要

Endocrine disrupting compounds present in the aquatic environment could cause side effect on aquatic organisms Previous studies have focused on estrogenic and androgenic compounds in the environment However natural and synthetic (anti)glucocorticoids and (anti)mineralocorticoids which are frequently used as pharmaceuticals to treat various symptoms of human diseases can also be released into the aquatic environment In this study recombinant yeast bioassays were used to detect mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) disrupting activities in water and suspended solids (SS) samples collected from 9 Taiwanese rivers Also liquid chromatography tandem mass spectrometry (LC-MS/MS) was used to quantify potential MR and GR disrupting chemicals in the aquatic environment in Taiwan Bioassays results showed that no MR and GR agonist activities were detected in river samples In contrast MR antagonist activity was detected in water and SS samples of all target rivers (
獎項日期2015 8月 22
原文English
監督員Pei-Hsin Chou (Supervisor)

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