Investigation of the beneficial effects of lovastatin on traumatic brain injury

論文翻譯標題: 探討 Lovastatin對於創傷性腦損傷的治療效果及其機轉
  • 蔡 立宸

學生論文: Master's Thesis


Traumatic brain injury (TBI) is a common cause of death and acquired disability in the developing and developed countries Currently no drug has been proved effective enough to treat TBI therefore treatment of TBI remains necessary Here we found lovastatin pretreatment had beneficial effects on TBI rats TBI rats displayed depression-like and anxiety-like behavior compared to sham-operated rats TBI rats also exhibited significantly higher level of Fluoro-Jade? C positive cells infarct volume Glial fibrillary acidic protein (GFAP) and tumor necrosis factor alpha (TNF?) as compared to sham-operated rats in hippocampal dentate gyrus Pretreatment of lovastatin significantly improved these adverse effects of TBI However the beneficial effects of lovastatin pretreatment were blocked by AMPK inhibitor Compound C Taken together these results demonstrate that lovastatin pretreatment ameliorates fluid percussion-induced brain injury depression and anxiety and these effects are likely mediated by AMPK signal
獎項日期2017 七月 21
監督員Po-Wu Gean (Supervisor)