Low-Frequency Transcutaneous Electrical Nerve Stimulation Suppresses Skin/Muscle Incision and Retraction-induced Postoperative Pain in Rats

論文翻譯標題: 低頻經皮神經電刺激減緩大鼠接受皮膚/肌肉切開與撐開術後之疼痛
  • 陳 郁蓁

學生論文: Master's Thesis


Background and Purpose: Persistent postoperative pain is a common problem after the skin/muscle incision and retraction (SMIR) procedure The SMIR model has been introduced to develop pain hypersensitivity from the saphenous nerve (SPN) injury leading to allodynia and hyperalgesia Moreover the transcutaneous electrical nerve stimulation (TENS) is a common clinical treatment that reduces neuropathic pain and the applications of high-frequency (HF) and low-frequency (LF) TENS provide two theories of mechanisms Previous studies have shown LF is less effective than HF in post-surgical pain and other models However its underlying mechanism suggests whether LF TENS is reliable for pain relief from the SMIR surgery remains unclear Therefore the purpose of this study is to determine the effects of LF TENS suppressing SMIR-induced postoperative pain in rats Methods: Male Sprague-Dawley rats were randomly assigned to the following groups: skin/muscle incision and retraction (SMIR) group (1 week) skin/muscle incision and retraction (SMIR) group (4 weeks) sham operation group SMIR with LF TENS (SMIR+LF TENS) group (1 week) and SMIR with LF TENS (1 week) plus extensive behavior testing (SMIR+LF TENS) group von Frey filaments and Hargreaves plantar apparatus were used to assess the symptoms of neuropathic pain The SMIR+LF TENS groups received the TENS treatment set at 2 Hz and pulse width of 100 μs with a duration of 20 minutes per day (one time) and 5 days per week for one week The rats received their last treatments on POD 7 since the SMIR surgery Results: The SMIR-operated rats displayed short-term mechanical allodynia and thermal hyperalgesia on the ipsilateral hind paw on POD 3 for one week but long-lasting hyperalgesia persisted for four weeks after surgery (p
獎項日期2016 8月 3
監督員Ching-Hsia Hung (Supervisor)