Modulating effects of an NMDA receptor agonist on cocaine-associated memory extinction

論文翻譯標題: NMDA 受器促效劑對古柯鹼相關記憶消退的影響
  • 蔡 旖旎

學生論文: Master's Thesis


Drug-associated memory has been known to reinstate drug-seeking behavior during abstinence and consequently lead to relapse D-serine an endogenous ligand for the glycine site of the NMDA receptor has been documented to interfere cocaine memory expression Sodium benzoate is reported to inhibit the activity of d-amino acid oxidase an enzyme catalyzing d-serine and thus to enhance d-serine accumulation and increase activation of NMDA receptor indirectly In this study we decided to investigate whether sodium benzoate can modulate the drug-associated memory Two paradigms of drug memory processes were used: (1) reconsolidation-related protocol and (2) new learning(extinction)-related protocol Cocaine-induced CPP was used to indicate the cocaine memory Systemic pretreatment with intraperitoneal sodium benzoate at 500 mg/kg (but not 250 mg/kg) before each reconsolidation trail reduced subsequent cocaine-induced CPP magnitude It was of importance to note that such a sodium benzoate treatment did not produce nontargeting effect in subsequent cocaine-induced CPP Moreover such a dosing regimen did not affect locomotor activity in a 30-min free navigation test Furthermore intra-mPFC injections of sodium benzoate before each reconsolidation trail perform a directly effect to reduce cocaine seeking behavior These results taken together suggest that sodium benzoate could be beneficial as a potential medicine of choice in reducing cocaine relapse
獎項日期2014 八月 21
監督員Lung Yu (Supervisor)