The incidence of necrotizing fasciitis in Taiwan: a nationwide population-based study

摘要

In Asia little is known about nationwide population-based incidence of necrotizing fasciitis (NF) and its related epidemiological profiles including Taiwan The nationwide annual incidence rate of NF was determined by using Taiwan’s National Health Insurance inpatient claims data from 2005 to 2010 based on factors such as gender age year month occupation and region In addition the comorbidities as risk factors of incidence of NF were identified Finally annual mortality rate of NF was calculated and factors associated with the mortality were examined The overall average annual incidence rate (cases per 100 000 population) of those six years of hospitalized and operated-on patients with NF was 11 6 (95% CI: 11 4-11 8 CI: confidence interval) for both genders 14 9 (95% CI: 14 9-15 5) for males and 8 3 (95% CI: 7 9-8 3) for females The age-adjusted annual incidence rate was 10 7 (95% CI: 10 3-11 1) in 2005 and 12 3 (95% CI: 11 9-12 8) in 2010 The annual incidence rate increased with age peaked in August was the highest in southern Taiwan and correlated with monthly temperature The annual incidence rate of NF in Taiwan increased between 2005 and 2009 and slightly decreased in 2010 The mean mortality rate from 2005 to 2010 was 8 6% By year the highest annual mortality rate was 9 9% in 2006 and since then the rate decreased gradually by year Type II diabetes was showed as a protective factor of mortality As for incidence rate of NF factors such as peripheral vascular disorder type I diabetes type II diabetes and Cushing syndrome contributed to higher incidence rate in male patients while cerebrovascular disease hepatocellular carcinoma and type II diabetes contributed to higher incidence rate in female patients Among patients who were greater than or equal to 65 years old the incidence rate of NF appeared to be higher for those with cerebrovascular disease Generally speaking patients with elder age and liver cirrhosis have higher incidence and mortality rate of NF and these groups should therefore be given the first priority for prevention

獎項日期	2014 9月 4
原文	English
監督員	Tsung-Hsueh Lu (Supervisor)