The multifunctional hybrid nanomaterials designed for biomedical applications

摘要

My research interest is that design the novelty multifunctional nanomaterials and the unique properties materials were discovered by instrument In the application the nanomaterials had great potential to be used in the biomedical field The multifunctional hybrid nanomaterials be provided with special structure and diversity properties (optical magnetic and catalytic activity etc ) and even can be used to load intolerable in water or relative instability drug or agent and the use of characteristics of the material to drive the controlled release of drugs My research has developed three multifunctional hybrid nanomaterials each material has its own peculiarities and application and it will be divided into three topics for discussed in detail In the first research topic (Chapter2) the thermally induced cross-linked esterification occurs for the formation of eccentric inorganic-polymeric nanoparticles By taking advantage of eccentricity Ag-PSMA eccentric structure is converted to raspberry-like Au-based Janus nanoparticles In the second research topic (Chapter3) a new multifunctional nanoparticle to perform a near-infrared (NIR)-responsive remote control drug release behavior was designed for applications in the biomedical ?eld Di?erent from the previous studies in formation of Fe3O4-Au core-shell nanoparticles resulting in a spherical morphology the heterostructure with polyhedral core and shell was presented with the truncated octahedral Fe3O4 nanoparticle as the core over a layer of trisoctahedral Au shell The strategy of Fe3O4@polymer@Au was adopted using poly-L-lysine as the mediate layer followed by the subsequent seeded growth of Au nanoparticles to form a Au trisoctahedral shell Fe3O4@Au trisoctahedra possess high-index facets of {441} To combine photothermal and chemotherapy in a remote-control manner the trisoctahedral core-shell Fe3O4@Au nanoparticles were further covered with a mesoporous silica shell yielding Fe3O4@Au@mSiO2 The bondable oligonucleotides (referred as dsDNA) were used as pore blockers of the silica shell that allowed the controlled release resulting in a NIR-responsive DNA-gated Fe3O4@Au@mSiO2 nanocarrier Taking advantage of the magnetism remotely triggered drug release was facilitated by magnetic attraction accompanied by the introduction of NIR radiation DNA-gated Fe3O4@Au@mSiO2 serves as a drug control and release carrier that features functions of magnetic target MRI diagnosis and combination therapy The results veri?ed the signi?cant therapeutic e?ects on tumors with the assistance of combination therapy consisting of magnetic guidance and remote NIR control In the third research topic (Chapter4) Since its discovery in 1894 the Fenton reaction Fe2+ + H2O2 → Fe3+ + ‧OH + OH? has been used to treat wastewater and contaminated soil and oxidize organic pollutants Apart from the reactive oxygen species (ROS) manipulation strategies known as chemotherapy radiotherapy and phototherapy the merge of nanotechnology with old chemistry without electromagnetic waves and O2 creates an appealing exogenous and controllable ROS-generating platform to produce ROS that acts against cancer cells Hydrogen peroxide-encapsulated Fe3O4-embedded poly(lactic-co-glycolic acid) polymersomes produce ROS at a temperature as low as 39 °C the temperature a human body can withstand for killing cancer cells

獎項日期	2015 7月 22
原文	English
監督員	Chen-Sheng Yeh (Supervisor)